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A new perspective on macrophage-targeted drug research: the potential of <i>KDELR2</i> in bladder cancer immunotherapy.

Front Immunol · 2024 · PMC11649672 · PMID 39691708

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The results showed that pathways such as mitochondrial electron transport, NADH to ubiquinone; oxidative phosphorylation and ATP synthesis coupled electron transport showed a positive enrichment trend, by comparison, pathways such as adaptive immune response and extracellular structure organization showed a trend of negative enrichment in this genome. 3.2 Visualization analysis of bladder cancer tissue cells The findings of various studies have demonstrated that the presence of TCs can trigger significant alterations at a molecular, cellular, and physical level within the surrounding tissue, leading to the formation of a specialized environment known as the TME.

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The stemness score of bladder cancer cells exhibited a slightly higher level compared to that of paracancerous cells; however, the difference did not reach statistical significance ( Figure 2H ). 3.3 Heterogeneity of stemness and development in bladder cancer cell subpopulations Subsequently, we conducted an analysis of gene expression related to cell stemness in the subpopulations of TCs.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.