PPARβ/δ upregulates the insulin receptor β subunit in skeletal muscle by reducing lysosomal activity and EphB4 levels.

GW501516 also showed a trend to increase p62 protein levels in adipose tissue (Fig. 2 D).

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Treatment with A769662 caused a slight recovery in the protein levels of the InsRβ that did not reach statistical significance (Fig. 3 F).

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