A safe insect-based chikungunya fever vaccine affords rapid and durable protection in cynomolgus macaques.

We also observed a general increase in expression of interferon (IFN)-related and Th1-associated transcripts, although these narrowly failed to reach statistical significance: log FC 1.1 IFNG ( P = 0.1898); 1.19 IFNGR1 ( P = 0.4269); 1.54 IFNGR2 ( P = 0.1339); 1.19 IL12RB1 ( P = 0.1883); 1.34 IL12RB2 ( P = 0.1854); 1.43 JAK1 ( P = 0.1699); 1.38 JAK2 ( P = 0.2142); 1.36 STAT1 ( P = 0.0856); and 1.51 STAT4 ( P = 0.2214) (Supplementary Data 2 ).

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Furthermore, EILV/CHIKV-vaccinated macaques showed a trend of stronger neutralization titers and higher E2 binding IgG responses at day 4 PC (Fig. 6C, D ).

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