Adjuvant rituximab and elevated intratumoural CD8 expression are associated with sustained disease control after radiotherapy in a randomised trial of systemic therapy in early-stage follicular lymphoma.

52% (95% CI = 31.8–63.2) treated in early-era (IFRT + CVP only) although this did not reach statistical significance (HR = 0.51, 95% CI = 0.15–1.79; p = 0.29) ( Fig. 2 F).

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In TROG99.03, presence of extranodal disease (most likely explained by the inclusion of cases of duodenal FL) 16 approached significance for association with superior PFS.

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On stepwise multivariable analysis of prognostic factors, only extranodal involvement (HR = 0.14, 95% CI = 0.02–1.01, p = 0.05) approached significant association with PFS.

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