ART26.12, a novel fatty acid-binding protein 5 inhibitor, shows efficacy in multiple preclinical neuropathy models.

Eur J Pain · 2025 · PMC11671339 · PMID 39188040

Europe PMC DOI

hedged sentences

0.0529

closest p · 1.1× alpha

0.0684

boldest claim

The sentences

a strong trendp = 0.0529so close (0.05 < p ≤ 0.1)

In female rats, PWTs in the vehicle group were significantly different from HBL on Day 11 ( p = 0.0313), Day 16 ( p < 0.0001) and Day 19 ( p = 0.0028), with a strong trend towards significance on Day 15 ( p = 0.0529).

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showed a trendp = 0.0684so close (0.05 < p ≤ 0.1)

On Day 17, ART26.12 (100 mg/kg BID) showed a trend towards reversal of mechanical allodynia ( p = 0.0684).

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