Mesenchymal Stem Cell Plasticity: What Role Do Culture Conditions and Substrates Play in Shaping Biomechanical Signatures?

Additionally, a highly significant correlation was found between the stiffness of ObJPCs and the degree of cell mineralization (row calcium concentration vs.

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JPC and iMSC Mineralization Potential Correlates with Cellular Biomechanical Fingerprint A negative correlation was observed between the stiffness of CaP precipitates and Young’s moduli of ObJPCs, although this did not reach statistical significance ( Table 1 ).

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Notably, gelatin appeared slightly more favorable for JPCs under hypoxic conditions, while iMSCs in the same conditions showed a trend toward producing firmer and larger amounts of CaP precipitates on laminin.

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