Differing Effects of Alcohol Use on Epigenetic and Brain Age in Adult Children of Parents with Alcohol Use Disorder.

Brain Sci · 2024 · PMC11674551 · PMID 39766462

Europe PMC DOI

hedged sentences

0.0940

closest p · 1.9× alpha

0.0940

boldest claim

The sentences

near-significantp = 0.094so close (0.05 < p ≤ 0.1)

The post hoc testing of the main effect of ACoA status demonstrated a near-significant difference between the control participants and the hazardous ACoA group (mean difference = 2.568, q(125) = 2.994, p = 0.094).

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approaching significanceno p-value reported

With frontal regions still undergoing maturation, it is possible that the predicted brain age differences observed in the hazardous ACoA group (and approaching significance within the non-hazardous ACoA group) reflect a delayed process of cortical maturation of frontal regions rather than the accelerated brain aging often observed with studies examining alcohol use disorders and psychiatric conditions using brain age estimations in older participant groups.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.