Is Polyhexamethylene Guanidine and Oligo(2-(2-Ethoxy) Ethoxyethyl Guanidium Chloride Exposure Related to Gestational Diabetes?

However, the p for the trend for cumulative exposure duration was significant (adjusted p = 0.009), while the trend for cumulative exposure hours approached significance (adjusted p = 0.059).

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Specifically, increasing cumulative exposure duration and cumulative exposure hours showed a trend toward increasing GDM risk.

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Episodes were excluded if they had twin or preterm deliveries (26 episodes), if they had been diagnosed with diabetes mellitus (DM) prior to conception (4 episodes), if they had incomplete exposure surveys (12 episodes), or if the date of the index delivery was more than five years after exposure cessation (50 episodes), as severe pregnancy outcomes were observed to manifest within a latency period after HD exposure, with a decreasing trend after 2017 [ 22 ].

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