Interactions Between Endocannabinoid and Endogenous Opioid Systems Prospectively Influence Postoperative Opioid Use in Pregnant Patients Undergoing Cesarean Delivery.

J Pain · 2024 · PMC11682609 · PMID 38663651

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0910

boldest claim

The sentences

approached significanceP = .054so close (0.05 < p ≤ 0.1)

GLM results for the days of opioid use outcome only approached significance for the BE × Plasma 2-AG interaction ( P = .054), so this interaction was not further interpreted.

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approaching significanceP = .060so close (0.05 < p ≤ 0.1)

Simple effects analyses indicated that there was a significant inverse association between plasma AEA and average pain intensity (ie, higher preoperative AEA was associated with lower postoperative pain) only in the low CSF BE group (beta = −3.009, SE = 1.298, P = .025) whereas there was a positive association approaching significance noted in the high BE group (beta = 3.003, SE = 1.557, P = .060).

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a nonsignificant trendP = .091so close (0.05 < p ≤ 0.1)

Results for CSF 2-AG revealed only a nonsignificant trend for interaction between CSF BE and CSF 2-AG ( P = .091), so this interaction was not pursued further.

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