Understanding the synergistic interaction between a 1,3,4-thiadiazole derivative and amphotericin B using spectroscopic and theoretical studies.

Even though in both the DMSO and PBS systems the registered decrease in the fluorescence anisotropy values was not particularly extensive, it nonetheless underscored a clear trend in the interactions between C1 and AmB molecules, one that is consistent with the hypothesized disaggregation of AmB molecules under the influence of the C1 1,3,4-thiadiazole molecules.

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The results were further corroborated by the measurements of fluorescence lifetimes, which showed a trend towards values characteristic of the 1 , 3 , 4 -thiadiazole molecule with the increasing concentration thereof in the system.

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