JAK inhibition decreases the autoimmune burden in Down syndrome.

Although some participants and caregivers reported benefits in terms of fewer flares and of lesser severity, the MSS metric did not show a clear trend, which may reveal the need for more frequent or different types of monitoring for HS, a condition that cycles periodically in severity.

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Although this T cell subset is mildly elevated (in terms of frequency among T cells) in individuals with Down syndrome, the result did not reach statistical significance after multiple hypothesis correction.

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