Effect of immune checkpoint inhibitor time-of-day infusion on survival in advanced biliary tract cancer: a propensity score-matched analysis.

This trend did not reach statistical significance after multivariate Cox regression adjustment (HR: 1.63, 95% CI: 0.96–2.75, p = 0.069).

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In contrast, PFS showed a nonsignificant trend toward poorer outcomes in patients with ≥20% of infusions after 16:30 in the unmatched cohort (median PFS: 5.0 months, 95% CI: 4.5–9.4) compared to those with <20% (median PFS: 9.4 months, 95% CI: 7.9–10.7) (HR: 1.62, 95% CI: 1.00–2.62, p = 0.052, Figure 5 ).

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In the subgroup of patients receiving first-line ICI plus chemotherapy, later ICI infusion showed a trend toward poorer PFS, but this did not reach statistical significance, potentially due to the relatively small sample size of this subgroup.

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