Genome-wide characterization of 54 urinary metabolites reveals molecular impact of kidney function.

Nat Commun · 2025 · PMC11696681 · PMID 39746953

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hedged sentences

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closest p · 1.0× alpha

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boldest claim

The sentences

nominally significantp < 0.05actually significant

31 by including as IVs only the eGFR-associated genetic variants ( p < 5 × 10 −8 ) with additionally having directionally consistent and nominally significant p-value (p < 0.05) with i) eGFRcys or ii) BUN.

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showed a trendno p-value reported

Furthermore, the glycine association in the GM2A gene showed a trend in the opposite direction in the FinnDiane study compared to the two general population studies.

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