MTAP protein status is highly concordant with CDKN2A fluorescent in situ hybridization and allows stratification of the luminal subtype in muscle-invasive bladder cancer.

Histopathology · 2025 · PMC11707494 · PMID 39327852

Europe PMC DOI

hedged sentences

0.3360

closest p · 6.7× alpha

0.3360

boldest claim

The sentences

did not reach statistical significanceP = 0.336not close (p > 0.1)

Mean RFS and OS were shorter for patients with MTAP loss (RFS: 23 months, OS: 24 months) compared to those with retained MTAP (RFS: 29 months, OS: 31 months), although these differences did not reach statistical significance ( P = 0.336 for RFS and P = 0.703 for OS; Figure 4 ).

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showed a trendno p-value reported

Further, MTAP loss showed a trend towards shorter RFS and OS, but did not reach statistical significance, possibly due to the limited sample size and variable follow‐up times.

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