The selective serotonin reuptake inhibitor paroxetine improves right ventricular systolic function in experimental pulmonary hypertension.

Vehicle-treated SuHx rats exhibited pronounced RV systolic dysfunction, evident by a significantly lower stroke volume ( p < 0.05), cardiac output ( p < 0.01) and a near-significant ∼30 % reduction in ejection fraction ( p = 0.07) compared to the Control group (all Table 2 ).

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SuHx+Vehicle, Table 2 ) and a ∼ 20 % higher ejection fraction although this difference did not reach statistical significance ( Table 2 ).

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