Loss of CHOP Prevents Joint Degeneration and Pain in a Mouse Model of Pseudoachondroplasia.

All scoring systems showed a trend towards a higher level of damage for the MT-COMP joints compared to controls, but only the early scoring system showed a significant difference.

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Although the total degeneration score for MT-COMP/CHOP −/+ showed a decreasing trend, only the bone/cartilage damage score was significantly different compared to the MT-COMP mice score ( Figure 3 ). 2.4.

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MT-COMP joints trended towards higher scores in synovitis and bone/cartilage damage, and the total score was comparable to controls, with P values approaching significance.

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