Efficacy and Safety of a Mixture of Microencapsulated Sodium Butyrate, Probiotics, and Short Chain Fructooligosaccharides in Patients with Irritable Bowel Syndrome-A Randomized, Double-Blind, Placebo-Controlled Study.

In contrast, a recent study with oral administration of Limosilactobacillus reuteri ATCC PTA 6475 to IBS-D patients showed a trend toward reduced serum IL-6 levels compared to the placebo group ( p = 0.052) [ 44 ].

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At week 8 and 12 of the intervention, the percentage of patients reporting relief increased to 74.5% and 72.5% in the biotic group and 62.0% and 56.0% in the placebo group, but these differences did not reach statistical significance.

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