Roles for the long non-coding RNA <i>Pax6os1</i>/<i>PAX6-AS1</i> in pancreatic beta cell function.

25 A significant and near-significant downregulation of Pax6os1 in pancreatic islets could be observed after 4 weeks of treatment with ASOs in female and male mice, respectively ( Figure S5 related to Figure 3 ).

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In contrast, Pax6os1 KO female (but not male) mice under HFD displayed a tendency toward reduced body weight ( Figure 3 F) and significantly lower circulating glucose at 30 min ( p = 0.041) during the IPGTT, with a strong trend toward a lower AUC during the experiment (WT: 1212 ± 169 a.u. vs.

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