Lipid-mediated resolution of inflammation and survival in amyotrophic lateral sclerosis.

Brain Commun · 2025 · PMC11733686 · PMID 39816195

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0700

boldest claim

The sentences

nominally significantP = 1.91 × 10−07actually significant

In agreement with the LDA approach, the differential expression analysis revealed a nominally significant increase in the expression of RvE3 in pwALS at baseline compared to NNC (nominal P = 1.91 × 10−07), an upregulation seen in all pwALS phenotypes (1.33 × 10−06 < nominal P < 0.00314).

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did not reach statistical significanceP = 0.07so close (0.05 < p ≤ 0.1)

Higher ALSFRS-R at baseline did not reach statistical significance (HR: 1.04, 95% CI: 1.08, 0.997; P = 0.07).

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