Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease.

FTD mutation carriers with higher baseline CSF rejuvenation composite levels demonstrated slower global cognitive and functional declines, and slower plasma NfL increases which approached significance ( P = 0.078), relationships that were not evident in clinically normal non-carrier adults ( Table 2 ; Fig. 2 ; Supplementary Fig. 1 ).

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When examining specific cognitive domains within Alzheimer’s disease participants, higher rejuvenation protein levels associated with better episodic memory performances (B = 0.55, P = 0.003), but did not reach statistical significance for language or executive functioning performances ( P -values >0.50).

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