The Association Between Serum Gamma-Glutamyl Transferase and Gastrointestinal Cancer Risk: A Systematic Review and Meta-Analysis.

Cancer Med · 2025 · PMC11736428 · PMID 39817495

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a significant trendno p-value reported

GGT level quartiles also showed a significant trend for the HR of gastrointestinal cancers, implying a dose–response relation between GGT levels and the hazard for cancer incidence.

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failed to reach statistical significanceno p-value reported

Nevertheless, these findings failed to reach statistical significance (Table 2 and Figures S11–S13 ). 3.7.

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failed to reach significanceno p-value reported

Overall, four studies reported significantly higher colorectal cancer incidence, while the other three failed to reach significance. 3.3.1.

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a positive trendno p-value reported

We also show a positive trend of GGT levels with digestive cancer incidence after pooling 11 million subjects in the meta‐analysis.

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