Effects of diabetes and hypertension on macrophage infiltration and matrix expansion in the rat kidney.

In the combined model of diabetes and hypertension in TGR-STZ, the effect of both diseases on macrophage infiltration of the interstitial space appeared to be additive although the numerical difference between TGR and TGR-STZ failed to reach statistical significance (figure 2 ).

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Macrophage infiltration tended to slightly higher values in hypertensive, hyperglycemic rats, compared to hypertensive, normoglycemic animals but this trend did not reach statistical significance.

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