Inhibition of hippocampal interleukin-6 receptor-evoked signalling normalises long-term potentiation in dystrophin-deficient <i>mdx</i> mice.

Brain Behav Immun Health · 2025 · PMC11762146 · PMID 39867844

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0.0700

closest p · 1.4× alpha

0.9500

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approached significancep = 0.07so close (0.05 < p ≤ 0.1)

No overall differences were apparent between regions (F(2, 53) = 0.57, p = 0.57, two-way ANOVA) but strain differences approached significance (F(1, 53) = 6.46, p = 0.07), and decreased maximal respiration was detected in the CA1 region of mdx hippocampal tissue relative to WT (p < 0.05).

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approaching significancep = 0.95not close (p > 0.1)

Under these conditions, basal respiration was lower in all three hippocampal regions in mdx relative to WT mice, revealing a significant strain effect (F(1, 62) = 16.96, p = 0.001) with no differences between regions (F(2, 62) = 0.23, p = 0.8) and an interaction between the variables approaching significance (F(2, 62) = 0.06, p = 0.95, Fig. 7 D).

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