Chronic Rapamycin Prevents Electrophysiological and Morphological Alterations Produced by Conditional Pten Deletion in Mouse Cortex.

Cells · 2025 · PMC11764219 · PMID 39851507

Europe PMC DOI

hedged sentences

0.1450

closest p · 2.9× alpha

0.1450

boldest claim

The sentences

did not reach statistical significancep = 0.145not close (p > 0.1)

Although neurons from the Pten -/- neocortex usually generated fewer APs at each current step, the difference did not reach statistical significance (F (1,22) = 2.273 for genotype effect, p = 0.145).

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a strong trendno p-value reported

159 ± 19 MΩ in Pten -/- rapamycin, p < 0.05), but they displayed a strong trend of having a reduced time constant (4.4 ± 0.3 ms in Pten -/- vehicle vs. 2.8 ± 0.2 ms in Pten -/- rapamycin.

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