aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed ultrasound.

Over 5 and 10 days of in vitro observation, there was a marginal decrease in particle size and a slight increase in the absolute value of the zeta potential, although these differences did not reach statistical significance ( P > 0.05) (Fig. 1 C-D).

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Antitumor effects of the NPs in vivo With continued treatment, the tumor volume in the model group of mice continued to increase, whereas the aPDL1-DTX/PFP@Lipid + LIPUS group exhibited a significant trend toward tumor growth inhibition.

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