Innovative antifungal strategies: enhanced biofilm inhibition of <i>Candida albicans</i> by a modified tea tree oil formulation.

At 2 μg/mL, although the difference was not statistically significant (p ∼ 0.052), the result was close to significance, suggesting that inhibitory effects might begin to manifest at this concentration.

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For AMB, a significant inhibitory effect was observed as early as 0.1 μg/mL (p ∼ 0.022), with the significance increasing at higher concentrations, and a highly significant difference at 10 μL/mL (p ∼ 0.010).

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In summary, AMB demonstrated a significant inhibitory effect at 10 μg/mL, and while TTO did not reach statistical significance at 10 μL/mL (∼9121.7 μg/mL), the data suggest a notable inhibitory effect at this concentration (see Supplementary Table 2 ).

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The result for 5 μL/mL (∼4560.85 μg/mL) was close to significance (p ∼ 0.089), while at 10 μL/mL (∼9121.7 μg/mL), although not statistically significant, the difference approached significance (p ∼ 0.067), suggesting a considerable inhibitory potential at this higher concentration.

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