Barely Significant
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APOE4 and sedentary lifestyle synergistically impair neurovascular function in the visual cortex of awake mice.

Commun Biol · 2025 · PMC11779976 · PMID 39880935

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0.0700
closest p · 1.4× alpha
0.0740
boldest claim

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trending towards significancep = 0.07so close (0.05 < p ≤ 0.1)
Experiment duration significantly affected this PC ( p = 0.01), with APOE genotype trending towards significance ( p = 0.07; Supplementary Fig. 7i, j ).

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showed a trendp = 0.074so close (0.05 < p ≤ 0.1)
These velocity responses were less frequent in APOE4 mice (LMM of genotype * exercise * duration; main effect of genotype: p = 0.0043), as seen for vessel dilation responses, and showed a trend-level tendency to be less frequent over time ( p = 0.074; Fig. 5l ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.