Furthermore, the mRNA expression of antioxidant genes, including SOD1, SOD2, and CAT, was significantly increased or showed a trend toward statistical significance following LDHA inhibition in SV-ECs by siRNA-LDHA (Fig. 4J ).
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LDHA-mediated glycolysis in stria vascularis endothelial cells regulates macrophages function through CX3CL1-CX3CR1 pathway in noise-induced oxidative stress.
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Additionally, flow cytometry analysis of cochlear Mφ showed an increased proportion of CD86/CD206, though the percentage of pro-inflammatory CD86 + Mφ only approached tendency towards significance and no significant difference was observed in the percentages of anti-inflammatory CD206 + Mφ (Supplementary Fig.