Global metabolomic profiling of tumor tissue and paired serum samples to identify biomarkers for response to neoadjuvant FOLFIRINOX treatment of human pancreatic cancer.

Mol Oncol · 2025 · PMC11793008 · PMID 39545923

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0.1000

closest p · 2.0× alpha

0.1000

boldest claim

The sentences

showed a trendP < 0.1so close (0.05 < p ≤ 0.1)

In addition, three pathways showed a trend towards significant enrichment ( P < 0.1): alanine, aspartate and glutamate metabolism, thiamine metabolism, and pyrimidine metabolism (Fig. 7B ). 4.

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did not reach statistical significanceP < 0.1so close (0.05 < p ≤ 0.1)

Moreover, a trend towards different abundance of histidine, phenylalanine, tryptophan, cystine, and tyrosine was seen in tissue samples, but the differences did not reach statistical significance ( P < 0.1; Table 3 ). 3.3.

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