Edaravone dexborneol alleviates pericyte-mediated fibrosis depositing extracellular matrix through TGF-β1/IL-11 in cerebral small vessel disease.

However, PDGFRβ expression exhibited a decreasing trend after EDB treatment, but did not reach statistical significance.

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In the corpus callosum, COL1A1 expression showed a significant increase in CCH mice, and the high EDB-treated mice showed a trend of reduced expression, but this did not reach statistical significance (Figure S4).

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The EDB-treated CCH mice showed a trend toward less rCBF reduction at 14 days and 30 days after surgery compared to the CCH mice, but this difference was not statistical significance (Figure S1 A, B).

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