U-shaped association between TC/HDL-C ratio and osteoporosis risk in older adults.

Additionally, after adjusting for all covariates, each 10 mg/dL increase in TC was associated with a 2% reduction in the odds of osteoporosis (OR: 0.98, 95% CI: 0.95–1.00), while each 10 mg/dL increase in HDL-C was associated with a 5% increase in the odds of osteoporosis (OR: 1.05, 95% CI: 1.00–1.11, p = 0.07), though the latter did not reach statistical significance.

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A significant trend across quartiles was evident in all models ( p for trend < 0.05).

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