Secreted Apoe rewires melanoma cell state vulnerability to ferroptosis.

Congruently, the association between FPS and GPX4 expression also showed a negative trend, thus validating the predictive value of the score ( Fig. 7J ).

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Despite a certain variability across samples, we observed a clear trend indicating that Gpx4 protein levels increased in rhApoE3-melanomas both in untreated conditions and following IKE ( Fig. 6E ), whereas this was not the case in the parental, ApoE3-untreated, Yumm 3.3 melanomas ( Fig. 6E ).

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