Comprehensive coronary CT angiography in people living with HIV: a systematic review and meta-analysis.

The difference in median SIS showed a trend toward greater involvement in PLWH of 0.39 (−0.01 to 0.79, p=0.0589; I 2 =86%, p=0.001; figure 4 and online supplemental table 6 ) but also did not reach statistical significance.

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Secondary outcomes A sensitivity analysis of the ORs using a fixed rather than random effects model yielded similar results for all outcomes, except that the borderline significant OR for calcified plaque reached significance with a less conservative estimate of 95% CI ( onlinesupplemental figures 1 2 ). 20 21 There were insufficient data to mathematically pool coronary characteristics specific to plaque volume, plaque number, CAD-RADS 2.0 and high-risk plaque features.

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The prevalence of high-degree stenosis trended higher (22% (95% CI: 16% to 29%) and 17% (95% CI: 11% to 24%)) in PLWH with an OR of 1.34 (0.92–1.96, p=0.126; I 2 =67%, p=0.003; figure 3 and online supplemental table 5 ) but did not reach statistical significance.

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