Pathway-based network medicine identifies novel natural products for Alzheimer's disease.

Additionally, while both groups presented more platform location crosses than the control group did, this difference did not reach statistical significance (Fig. 5 l).

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Furthermore, when comparing the combination therapy to the standard treatment, Donepezil, the reduction in Aβ plaque burden in both the cortex and hippocampus was similar between the groups, while the combination group showed a trend towards lower levels of soluble Aβ.

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Methods Network-based identification of natural products Construction of the AD-related pathway-gene network In this study, we aimed to screen AD-related pathways from three perspectives: Most Studied Pathways (pathways with the most literature on AD), Gene-Associated Pathways (derived from AD-associated gene enrichment analysis), and Popular Pathways (pathways showing an increasing trend in the literature).

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