Next-Generation Sequencing-Based MSI Scoring Predicts Benefit in Mismatch Repair-Deficient Tumors Treated with Nivolumab: Follow-up on NCI-MATCH Arm Z1D.

Clin Cancer Res · 2025 · PMC11831103 · PMID 39670863

Europe PMC DOI

hedged sentences

0.1500

closest p · 3.0× alpha

0.2300

boldest claim

The sentences

a nonsignificant trendP = 0.15not close (p > 0.1)

We found a nonsignificant trend that JAK1 frameshift and nonsense mutations were more frequent in subjects without clinical benefit (33% vs. 7%; P = 0.15; two-sided Fisher exact test; Supplementary Fig.

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showed a trendP = 0.23not close (p > 0.1)

The corresponding survival analysis showed a trend toward higher probability of survival for subjects in the hot versus cold cluster (HR = 0.54; P = 0.23, log-rank test).

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did not reach statistical significanceno p-value reported

S7), although associations between response and specific immune infiltrating populations did not reach statistical significance.

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