Dissecting the rising tide of inflammatory bowel disease among youth in a changing world: insights from GBD 2021.

Although ASRs in the mid-SDI region were not significantly higher or lower than in other areas (2.3 per 100,000; 95% CI, 1.8 to 3.1), the upward trend was most substantial (EAPC = 1.97; 95% CI, 1.72 to 2.22) (Table 2 ). Examining the annual time series from 1990 to 2021, the incidence in higher SDI regions showed a trend from increasing to decreasing in several areas, excluding Eastern Europe, while regions with moderate or lower SDI continued a slow increase.

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For instance, if the analysis detects a significant trend change (such as a sharp increase or decrease) in a specific year, that year is considered a “Inflection point,” and the corresponding APC for that segment is calculated.

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