Barely Significant
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The Efficacy and Safety of Synchronized Radiofrequency and High Intensity Facial Electrical Stimulation in Improving Facial Skin Laxity and Quality in Asians.

Lasers Surg Med · 2025 · PMC11844716 · PMID 39800907

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a positive trendno p-value reported
Skin wrinkle improvements, particularly in the crow's feet area, approached statistical significance ( p = 0.049), indicating a positive trend towards smoother skin.

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a trend towards significanceno p-value reported
Similarly, cheek lifting improved initially and maintained a trend towards significance at 6 months.

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While forehead and cheek textures improved, they did not reach statistical significance, possibly due to the small sample size or variations in individual responses.

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Strengthening of these muscles via the HIFES technology can explain the sustained lifting response seen even at 6 months in the forehead and eyebrow with the cheek lift trending towards significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.