Intradermally injected abobotulinumtoxinA administered preemptively before surgery alleviates post-surgical pain and normalizes behavior in a translational animal model.

Part A The two groups to be injected with either aboBoNT-A or saline were similar in the initial body weight, whereas after treatment aboBoNT-A-treated animals showed a trend of faster weight gain in comparison to saline treated controls (Table S1 ).

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The rate of DBS decline was somewhat faster in aboBoNT-A-treated animals than in saline-treated controls on Days 2 and 3, but the difference between the groups did not reach statistical significance (Fig. 6 C).

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