Phosphatidylserine as a tumor target for CAR-T cell therapy.

However, reduced Anxa CAR expression showed a trend towards decreasing the percentage of PD-1 + CD137 + cells, although still evidenced a high expression of CD69 ( figure 6D ) and a high percentage of TIM3 + LAG3 + cells, indicating basal activation possibly triggered by the recognition of PS in the CAR-T cell membrane ( figure 6E ).

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While the combined therapy of EDA CAR-T cells and EDAnnexin protein exhibited a modest enhancement in the antitumor response, these improvements did not reach statistical significance ( figure 3C ).

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