Mitochondrial Dysfunction Correlates with Brain Amyloid Binding, Memory, and Executive Function in Down Syndrome: Implications for Alzheimer's Disease in Down Syndrome.

PCr recovery half-time significantly correlated with CAMCOG-DS memory domain scores (r = −0.755, p = 0.012; Figure 2 b) and showed a trend toward correlation in praxis (r = −0.628, p = 0.052; Figure 2 c) and perception (r = −0.570, p = 0.085; Figure 2 d) domains.

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A trend toward significance was observed in the frontal (r = 0.622, p = 0.055; Figure 1 b) and parietal (r = 0.567, p = 0.088; Figure 1 c) regions, as well as for combined frontal, parietal, and striatal binding (r = 0.564, p = 0.09; Figure 1 d).

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When age effects were controlled, PCr recovery half-time accounted for 60% of the variation in CAMCOG performance, though the correlation did not reach statistical significance (r = −0.6, p = 0.088).

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