Effects of Chronic Alcohol Intake on the Composition of the Ensemble of Drug-Metabolizing Enzymes and Transporters in the Human Liver.

J Xenobiot · 2025 · PMC11856820 · PMID 39997363

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.1000

boldest claim

The sentences

approaching significancep = 0.06so close (0.05 < p ≤ 0.1)

A reduction in UGT1A1 approaching significance (FC 1.5, p = 0.06) was also observed.

also in 943 other papers

approached significancep -value = 0.10so close (0.05 < p ≤ 0.1)

A decrease in CYP2D6 levels approached significance (FC 0.68, p -value = 0.10) in heavy drinkers.

also in 2,641 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.