Carbon dioxide laser excision as a novel treatment for large xanthelasma palpebrarum: long-term efficacy and safety.

The incidence of scarring across the grades—grades I–IV (with distinctions based on lesion size)—showed a trend towards increased scarring with higher lesion grades, with rates ranging from 3.3% in grade I to 50.0% in grade IV lesions larger than 10 cm2 (p=0.002).

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Hyperpigmentation rates varied from 7.7% in grade I to 14.3% in grade IV (size ≤10 cm2), though these differences did not reach statistical significance (p=0.918).

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