Intestinal Akkermansia muciniphila complements the efficacy of PD1 therapy in MAFLD-related hepatocellular carcinoma.

Cell Rep Med · 2025 · PMC11866522 · PMID 39798567

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did not reach statistical significanceno p-value reported

As shown in Figures S1 C and S1D, our findings revealed that Akk demonstrated a tendency to suppress HCC tumors and improve the effectiveness of PD1 therapy, although the results did not reach statistical significance.

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showed a trendno p-value reported

The treatment with FMT from PD1 responder patients showed a trend of potentiating the PD1 therapy, which is in line with previous study showing the sensitization of PD1 treatment upon FMT. 53 The efficiency can be further improved by increasing the limitation of sample size, treatment frequency, and FMT quantity.

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