The microglial response to inhibition of Colony-stimulating-factor-1 receptor by PLX3397 differs by sex in adult mice.

In agreement with previous reports, we observed comparable microglia density between sexes 26 and a trend toward smaller soma size in females compared to males in the hippocampus, 27 which did not reach statistical significance ( Figure S1B ).

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Interestingly, we observed significantly higher levels of TREM2 in Galectin-3 + microglia compared to Galectin-3 − microglia in both control and PLX groups of both sexes and an increase in TREM2 expression in Galectin-3 − microglia after PLX treatment, which approached significance in males ( Figures 5K and 5L ).

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