Determinants of response and molecular dynamics in HER2+ER+ breast cancers from the NA-PHER2 trial receiving HER2-targeted and endocrine therapies.

Nat Commun · 2025 · PMC11880565 · PMID 40038334

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0530

boldest claim

The sentences

reached borderline significancep = 0.053so close (0.05 < p ≤ 0.1)

Association of intra-tumoral TILs with pCR reached borderline significance at Day14 ( p = 0.053, Fig. 2H ), while TIL dynamics between baseline and Day14 were not more informative (Supplementary Fig. 5G, H ).

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did not reach statistical significanceno p-value reported

Association of the four response groups with baseline PIK3CA or TP53 mutation and PAM50 classification, did not reach statistical significance (Supplementary Fig. 13A–C ).

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