Although PFC-VTA coherence also showed a trend toward a slow decrease by 4 weeks after irradiation in sham controls, the depression in the Delta and Theta bands persisted, suggesting a lasting alteration in the functional connectivity between the VTA and PFC within the mesocortical network (Fig. 6 D-G).
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Cranial radiation disrupts dopaminergic signaling and connectivity in the mammalian brain.
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Although there was also a trend toward a decrease in the total number of arm entries in this group, this difference did not reach statistical significance (Fig. 5 D).