Mild traumatic brain injury increases vulnerability to post-traumatic stress disorder in rats and the possible role of hippocampal DNA methylation.

Compared with the PTSD group, rats in the mTBI + PTSD group showed a trend toward less time in the Q quadrant, suggestive of impaired spatial memory; nevertheless, the difference was not statistically significant ( p = 0.1296).

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However, these effects did not reach statistical significance, suggesting that the intensity of the TBI induced in our study was indeed mild and was likely at the very low end of the mTBI continuum.

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