An analysis of the mediating influence of depression on the association between early-life caregiver relationships and cognitive function: a cohort study based on the CHARLS database.

Front Psychiatry · 2025 · PMC11914091 · PMID 40104328

Europe PMC DOI

hedged sentences

0.6520

closest p · 13.0× alpha

0.6520

boldest claim

The sentences

failed to achieve significancep = 0.652not close (p > 0.1)

Furthermore, other potential mediators failed to achieve significance (mean estimate = -2.748572, 95% CI: -17.703305 to 15, p = 0.652).

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did not reach statistical significanceno p-value reported

Additionally, both rural and urban male residents scored significantly lower, and Han Chinese men scored significantly lower than ethnic minority men, though the results for minority men did not reach statistical significance.

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approached significanceno p-value reported

Furthermore, men without diabetes scored significantly lower, while the scores for men with diabetes approached significance.

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highly significantno p-value reported

The key findings are outlined below: 3.5 Total score, depression, and dementia Our results indicate that, in the link between total score and dementia, the indirect effect of total score via depression was highly significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.