Picropodophyllin, an IGF‑1 receptor inhibitor, enhances oxaliplatin efficacy in chemoresistant colorectal cancer HCT116 cells by reducing metastatic potential.

Oncol Lett · 2025 · PMC11916648 · PMID 40103601

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did not reach statistical significanceno p-value reported

Additionally, whilst the combination of PPP and OX (53 μM) led to a reduction in migration in HCT116 cells compared with OX alone, this decrease did not reach statistical significance.

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an increasing trendno p-value reported

As EMT serves a crucial role in acquired resistance, there is an increasing trend towards agents that increase treatment sensitivity by targeting EMT inhibition ( 16 , 43 – 45 ).

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showed a trendno p-value reported

Whilst the higher concentration of OX (324 μM) combined with PPP (1 μM) showed a trend toward greater cytotoxicity in resistant cells, this difference was not statistically significant.

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