Longitudinal quantitative assessment of retinal crystalline deposits in bietti crystalline dystrophy.

The inner ring showed highly significant decrease in crystal area fraction from baseline (1.056 ± 0.208%) to one year (0.547 ± 0.208%, P = 0.003) and two years (0.411 ± 0.208%, P < 0.001).

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In the outer ring, a trend toward reduction was observed, with borderline significance at two years (baseline: 1.001 ± 0.155%, two years: 0.722 ± 0.155%, P = 0.086).

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In the outer ring, the crystal area showed a trend toward reduction from baseline (0.247 ± 0.051 mm2) to one year (0.216 ± 0.046 mm2, P = 0.492) and two years (0.176 ± 0.050 mm2, P = 0.151), though these changes did not achieve statistical significance.

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The mean crystal area in the central foveal ring showed a modest reduction from baseline (0.008 ± 0.004 mm2) to one year (0.007 ± 0.004 mm2, P = 0.762) and two years (0.005 ± 0.004 mm2, P = 0.415), though these changes did not reach statistical significance.

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